What is Trimix?
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PGE-1 / Bimix / Trimix / Quadmix
Trimix is an injectable medication consisting of papaverine, phentolamine, and alprostadil, which is used to treat erectile dysfunction (ED). The administration of Trimix injections can induce an erection in as little as five minutes and can lead to sustained and more rigid erections that persist through climax. As the dosages of Trimix are tailored to the individual needs of each patient, it is necessary to obtain a prescription from a healthcare provider.
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Trimix Benefits
Tri-mix injections offer several advantages over alternative medications for erectile dysfunction (ED) treatment, such as:
- Swift onset with prolonged duration
- Straightforward and minimally invasive administration
- Demonstrated high efficacy in clinical evaluations
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Who Should Use Trimix?
Trimix may be suggested for men with erectile dysfunction as an alternative to PDE5 inhibitors if they have proven ineffective or resulted in side effects.
Some common risk factors and conditions associated with ED include:
- Low testosterone
- Cardiovascular disease
- Diabetes
- Prostate issues
- Depression
- Anxiety
- Neurological/spinal cord injury
Trimix may also be appropriate for patients with medical conditions that preclude taking oral ED drugs, such as men who’ve had prostate surgery or certain cardiovascular diseases, or for patients who cannot take PDE5 inhibitors due to concurrent nitrate therapy or certain beta-blockers.
What Are Trimix’s Components?
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Papaverine
Papaverine aids men with ED by enhancing blood flow to the penis, allowing patients to achieve and sustain a firm erection for sexual intercourse. When used alone, papaverine is often prescribed for patients with circulatory disorders to improve blood flow.[5] As a vasodilator, papaverine relaxes and widens blood vessels, facilitating blood circulation to the heart and body. Furthermore, papaverine relaxes smooth muscle inside large blood vessels, particularly the coronary, systemic peripheral, and pulmonary arteries, with minimal effects on the central nervous system.
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Phentolamine
Phentolamine is a long-acting adrenergic alpha-receptor blocker that increases blood flow to the skin, mucous membranes, abdominal organs, and reduces blood pressure.[6] Phentolamine works by obstructing alpha receptors in the body, which are present in the smooth muscle lining blood vessel walls. When these alpha receptors are blocked by phentolamine, the muscles relax and blood vessels dilate, producing a significant boost in circulation.
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Alprostadil
Additional ED Treatment Options
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Atropine
Recent clinical interest has highlighted atropine’s potential in ED treatment, particularly through its ability to block muscarinic receptors at low doses and induce the release of endothelium-derived relaxing factor (EDR) at higher doses. This dual action suggests atropine could play a role in enhancing erectile function.
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Prostaglandin E1 (PGE-1)
Another notable component is PGE-1, recommended in doses ranging from 10-60 micrograms (mcg) for ED treatment. It’s a vasoactive agent that, like the other components of Trimix, helps in achieving erections by dilating blood vessels.
Reversal
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Phenylephrine (Erection Reversal)
In cases of prolonged erections, phenylephrine offers a solution. It should be injected using the same method as Trimix, but only after about 4 hours of sustained erection to prevent negative outcomes. Dosing with 0.5 ml and repeating every 5-10 minutes until the erection subsides is advised, but frequent use for erection “knock down” is not recommended due to potential risks.
Key points to remember about Trimix dosages:
Trimix Dosages
Trimix dosages are customized based on each patient’s needs.
Typically, the starting Trimix dosage should be 0.05-0.2 cc.
We recommend waiting 48 hours before increasing the dose, then going up by 0.025-0.05 cc until optimal results are achieved.
Wait 2-3 days between dose increases when beginning the drug.
Increase by 0.025-0.05 cc until you’re experiencing optimal results.
Phenylephrine is commonly used to reverse prolonged erections during dosage titration.
Typically, 0.25 - 0.6 cc of 1 mg/ml phenylephrine reverses the effects of Trimix adequately.
It's recommended to start with a lower dosage to avoid prolonged erections. After the first dose, the prescriber may adjust the dosage. Don’t be discouraged by a poor result with the first few injections, as the initial dose is kept low to prevent prolonged erections during dosage titration.
Trimix is not recommended for men with:
• Known allergies to Trimix ingredients
• Sickle cell anemia
• Bleeding disorders
• Conditions increasing priapism risk
• Leukemia
• Penile abnormalities
• Penile implants
• Explicit medical advice to refrain from sexual activity
It’s important to inform your provider of all medications, over-the-counter drugs, herbal products, and other substances you take. Trimix components can interact with some medications, potentially making them less effective or causing adverse reactions.
How Does Trimix Work?
Once Trimix is injected directly into the shaft of the penis, the compounded mixture of papaverine, phentolamine, and alprostadil triggers a vasodilation effect that causes the relaxation and expansion of blood vessels, allowing for the increased blood flow needed to achieve and sustain an erection.
Trimix can work quickly, triggering an erection within 5-10 minutes or less. Some men respond after foreplay begins. Erections typically last 1-2 hours with Trimix, often persisting through climax. Trimix is not designed to enlarge the size of the penis. However, it can help men with ED obtain and maintain a firm erection for longer periods.
With appropriate administration, Trimix can assist men in regaining their lost sexual function due to ED, enhancing their overall quality of life. Remember, erections lasting over 4 hours are a medical emergency requiring immediate care.
FAQ's
Hours of Availability
Online Availability Only: Monday - Sunday | 24 Hours
Office Hours: Monday - Friday | 10am - 5pm
Office Location
901 Fremont St, Las Vegas, NV, 89101 | STE 169
Office Number
725-239-9392
Email
ServiceSupport@srxvinc.com